Chronic Kidney Disease (CKD) also known as Chronic Renal Failure (CRF) is due to decreased functioning of Nephrons over years. The most common reasons of CRF being, Uncontrolled diabetes, Uncontrolled Hypertension, Irrational use of nephrotoxic drugs (commonly Painkillers), Glomerulonephritis, SLE, Urinary tract obstruction, Chronic pyelonephritis, Polycystic Kidney disease, Renovascular disease, Interstetial nephritis, Other causes like PAN, Amyloid, Myeloma.