Acute Promyelocytic Leukemia (APML) is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.
Migraine is the most common form of headache largely affecting urban population. About 15-17% of women and 5-7% of men are affected by this disorder. Though migraine may occur in all age groups, it is highly prevalent in the age group of18-45 years. Migraine attacks are characterized by recurrent headaches, unilateral/bilateral location, pulsating in nature with moderate to severe intensity causing debility. World Health Organization has ranked migraine as 19th among the debility causing diseases.
Children with recurrent cough, wheezing, chest tightness or shortness of breath may have one or more forms of asthma. Left untreated, asthmatic children often have less stamina than other children, or avoid physical activities to prevent coughing or wheezing. Sometimes they will complain that their chest hurts or that they can not catch their breath. Colds may go straight to their chest. Or, they may cough when sick, particularly at night. Asthma has multiple causes, and it is not uncommon for two or more different causes to be present in one child. Asthma is more than wheezing. Coughing, recurrent bronchitis and shortness of breath, especially when exercising, are also ways that asthma appears.
Chronic Pancreatitis (CP) is a continuing inflammatory disease of the pancreas with irreversible morphologic changes. It is characterized by moderate to severe pain in the upper abdomen radiating to middle of the back associated with nausea, vomiting, weakness and weight loss. Such symptoms might last from hours to two days and eventually could be continuous as the condition get worse. Inflammation of the pancreas that does not heal or improve it gets worse over time and leads to permanent damage. It occurs when digestive enzymes attack the pancreas and nearby tissues, causing episodes of pain. The symptoms may mimic Pancreatic Cancer as well.